HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Oxo-3-(3-pyridin-3-yl-phenyl)-propionic acid tert-butyl ester → {4-Fluoro-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Oxo-3-(3-pyridin-3-yl-phenyl)-propionic acid tert-butyl ester | HCID 11266473 | — |
| Reactant | N1-(tert-Butoxycarbonyl)-4-fluoro-1,2-phenylenediamine | HCID 24688763 | — |
| Product | {4-Fluoro-2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester | HCID 86589223 | — |
Reaction Steps
The title compound was prepared from (2-amino-4-fluoro-phenyl)-carbamic acid tert-butyl ester (Example J2) (83 mg, 0.37 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic acid tert-butyl ester (Example K1) (109 mg, 0.37 mmol) according to the general procedure M. Obtained as a light yellow amorphous substance (127 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-89089be75ce34120853321341fc378f6 |
| Source note | uspto-grants-2005_09 |