HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Oxo-3-(3-pyrimidin-5-yl-phenyl)-propionic acid tert-butyl ester → {4-Chloro-5-isobutylamino-2-[3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Oxo-3-(3-pyrimidin-5-yl-phenyl)-propionic acid tert-butyl ester | HCID 69486803 | — |
| Edukt | Carbamic acid,[2-amino-4-chloro-5-[(2-methylpropyl)amino]phenyl]-,1,1-dimethylethyl ester | HCID 69489120 | — |
| Produkt | {4-Chloro-5-isobutylamino-2-[3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionylamino]-phenyl}-carbamic acid tert-butyl ester | HCID 86589289 | — |
Reaktionsschritte
The title compound was prepared from (2-amino-4-chloro-5-isobutylamino-phenyl)-carbamic acid tert-butyl ester (Example J16) (235 mg, 0.75 mmol) and 3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionic acid tert-butyl ester (Example K13) (224 mg, 0.75 mmol) according to the general procedure M. Obtained as an off-white foam (260 mg, 64%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06949542B2 |
| Quelldatensatz | uspto-grants-2005_09 |
| ORD ID | ord-66bd1f21a6b744248010eeca137cd436 |
| Quellennotiz | uspto-grants-2005_09 |