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(2-Amino-4-chloro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester → (4-Chloro-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2-Amino-4-chloro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester | HCID 69487014 | — |
| 反応物 | 3-[3-(2-Methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester | HCID 69489307 | — |
| 生成物 | (4-Chloro-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester | HCID 86589292 | — |
反応手順
The title compound was prepared from (2-amino-4-chloro-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J24) (466 mg, 1.5 mmol) and 3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K12) (467 mg, 1.5 mmol) according to the general procedure M. Obtained as an orange oil (360 mg, 44%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06949542B2 |
| 出典データセット | uspto-grants-2005_09 |
| ORD ID | ord-c30e452880774f55a3b50d39669d27bc |
| 出典メモ | uspto-grants-2005_09 |