1,1-Dimethylethyl N-(2-amino-4-chlorophenyl)carbamate → HCID 86589303, compound

HRID 498338Notes

Reaction equation

HRID 498338 reaction equation
[C:1]([O:5][C:6](=[O:16])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:9]=1[NH2:15])([CH3:4])([CH3:3])[CH3:2].C([O:21][C:22](=O)[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[CH:37]=[C:36]([CH3:38])[N:35]=[C:34]([CH3:39])[CH:33]=2)[CH:27]=1)=[O:25])(C)(C)C>>[C:1]([O:5][C:6](=[O:16])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:9]=1[NH:15][C:22](=[O:21])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[CH:33]=[C:34]([CH3:39])[N:35]=[C:36]([CH3:38])[CH:37]=2)[CH:27]=1)=[O:25])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 574562721,1-Dimethylethyl N-(2-amino-4-chlorophenyl)carbamateHCID 694892403-[3-(2,6-Dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

Product 1

HCID 86589303HCID 86589303, compound

Procedure

The title compound was prepared from (2-amino-4-chloro-phenyl)-carbamic acid tert-butyl ester (Example J4) (243 mg, 1.0 mmol) and 3-[3-(2,6-dimethyl-pyridin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K15) (325 mg, 1.0 mmol) according to the general procedure M. Obtained as a light brown foam (240 mg, 49%).

Sources & evidence

ORD record
ord-2cdeb951fbd1487999477424c3574e10
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

Loading…