HRID498370

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1cc(NC(=O)OC(C)(C)C)c(N)cc1C(F)(F)F

HCID67361461

未命名化合物

结构：COc1ccc(-c2cccc(C(=O)CC(=O)OC(C)(C)C)c2)cn1

HCID69486695

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2cccc(C(=O)CC(=O)Nc3cc(C(F)(F)F)c(C)cc3NC(=O)OC(C)(C)C)c2)cn1

HCID86589335

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J20) (232 mg, 0.80 mmol) and 3-[3-(6-methoxy-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K10) (270 mg, 0.82 mmol) according to the general procedure M. Obtained as a yellow foam (287 mg, 66%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d5cdf44f4e3e4a858ce14a199bdf580f
来源数据集: uspto-grants-2005_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06949542B2
来源说明: uspto-grants-2005_09

反应 SMILES

[C:1]([O:5][C:6](=[O:20])[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=1[NH2:19])([CH3:4])([CH3:3])[CH3:2].C([O:25][C:26](=O)[CH2:27][C:28]([C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([C:36]2[CH:37]=[N:38][C:39]([O:42][CH3:43])=[CH:40][CH:41]=2)[CH:31]=1)=[O:29])(C)(C)C>>[C:1]([O:5][C:6](=[O:20])[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][C:9]=1[NH:19][C:26](=[O:25])[CH2:27][C:28]([C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([C:36]2[CH:37]=[N:38][C:39]([O:42][CH3:43])=[CH:40][CH:41]=2)[CH:31]=1)=[O:29])([CH3:4])([CH3:2])[CH3:3]