3-[3-(2-Ethyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester → HCID 86589400, compound

HRID 498435Notes

Reaction equation

HRID 498435 reaction equation
[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=1[NH2:24])([CH3:4])([CH3:3])[CH3:2].C([O:30][C:31](=O)[CH2:32][C:33]([C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([C:41]2[C:42]([CH2:47][CH3:48])=[N:43][CH:44]=[CH:45][CH:46]=2)[CH:36]=1)=[O:34])(C)(C)C>>[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][C:16]([F:18])([F:17])[F:19])[C:11]([C:20]([F:22])([F:23])[F:21])=[CH:10][C:9]=1[NH:24][C:31](=[O:30])[CH2:32][C:33]([C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([C:41]2[C:42]([CH2:47][CH3:48])=[N:43][CH:44]=[CH:45][CH:46]=2)[CH:36]=1)=[O:34])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 694867823-[3-(2-Ethyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl esterHCID 76849205Carbamic acid,[2-amino-5-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]-,1,1-dimethylethyl ester

Product 1

HCID 86589400HCID 86589400, compound

Procedure

The title compound was prepared from [2-amino-5-(2,2,2-trifluoro-ethoxy)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example J6) (281 mg, 0.75 mmol) and 3-[3-(2-ethyl-pyridin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K31) (244 mg, 0.75 mmol) according to the general procedure M. Obtained as an amorphous yellow substance (373 mg, 80%).

Workup

  1. customObtained as an amorphous yellow substance (373 mg, 80%)

Sources & evidence

ORD record
ord-e7f7845d26ae4ec4a3ad8186ac2fdcc8
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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