HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-N-(4-chlorophenyl)pyridine-3-carboxamide → N-(4-Chlorophenyl)-2-[1-(4-pyridyl)piperidin-4-ylmethyl]aminopyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-N-(4-chlorophenyl)pyridine-3-carboxamide | HCID 587906 | — |
| Reactant | [1-(Pyridin-4-yl)piperidin-4-yl]methanamine | HCID 10607746 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | N-(4-Chlorophenyl)-2-[1-(4-pyridyl)piperidin-4-ylmethyl]aminopyridine-3-carboxamide | HCID 12990573 | 24% |
Reaction Steps
Using a similar procedure to that described in Example 8, Part B, 2-chloro-N-(4-chlorophenyl)pyridine-3-carboxamide (125 mg, 0.47 mmol), 1-(4-pyridyl)piperidin-4-ylmethylamine (90 mg, 0.47 mmol), and triethylamine (0.07 mL) yielded 40 mg (24%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710057B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-16505e1677fa44da9c425c98f1e22133 |
| Source note | uspto-grants-2004_03 |