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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 498474Generated: October 29, 2026

(2-Amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester → HCID 86589439, compound

https://huagongshe.com/reaction/498474

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2-Amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl esterHCID 67361461—
ReactantHCID 69486907HCID 69486907—
ProductHCID 86589439HCID 86589439—

Reaction Steps

The title compound was prepared from (2-amino-5-methyl-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J20) (4.40 g, 15.0 mmol) and (RS)-3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionic acid tert-butyl ester (Example K40) (6.24 g, 15.0 mmol) according to the general procedure M. Obtained as a light yellow foam (6.20 g, 65%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06949542B2
Source datasetuspto-grants-2005_09
ORD IDord-752217d1b8b6474aac01e9a9d6794cdb
Source noteuspto-grants-2005_09