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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 498498Generated: October 30, 2026

tert-butyl N-(2-amino-4-(trifluoromethyl)phenyl)carbamate → [2-(3-[2,3']Bipyridinyl-4-yl-3-oxo-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/498498

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-butyl N-(2-amino-4-(trifluoromethyl)phenyl)carbamateHCID 24689211—
ReactantHCID 69489458HCID 69489458—
Product[2-(3-[2,3']Bipyridinyl-4-yl-3-oxo-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl esterHCID 86589463—

Reaction Steps

The title compound was prepared from (2-amino-4-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example J3) (214 mg, 0.75 mmol) and 3-[2,3′]bipyridinyl-4-yl-3-oxo-propionic acid tert-butyl ester (Example K57) (224 mg, 0.75 mmol) according to the general procedure M. Obtained as a yellow foam (268 mg, 71%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06949542B2
Source datasetuspto-grants-2005_09
ORD IDord-1bb6776e79be4ed2b417de425ce3f054
Source noteuspto-grants-2005_09