HRID4985

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID83170

L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-

C11H21NO4

结构：CC(C)C[C@H](NC(=O)CN)C(=O)N[C@@H](C)C(=O)OCc1ccccc1

HCID131717745

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)C(=O)N[C@@H](C)C(=O)OCc1ccccc1

HCID131717746

未命名化合物

PROCEDURE

实验过程

Boc-Leu-Gly-Leu-Ala-OBzl was prepared by coupling Boc-Leu-OH (2.62 g, 10.5 mmoles) to H-Gly-Leu-Ala-OBzl using the mixed anhydride procedure described in Example 2. The resulting product was crystallized from ethyl acetate:hexane to yield 2.7 g (mp 95°-96°) in the first crop.

WORKUP

后处理

customThe resulting product was crystallized from ethyl acetate
customhexane to yield 2.7 g (mp 95°-96°) in the first crop

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dcb3efb5c2714b649c6024418e3d449a
来源数据集: uspto-grants-1993_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05242904
来源说明: uspto-grants-1993_09

反应 SMILES

[NH:1]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C@H:2]([C:7]([OH:9])=O)[CH2:3][CH:4]([CH3:6])[CH3:5].[NH2:17][CH2:18][C:19]([NH:21][C@H:22]([C:27]([NH:29][C@H:30]([C:32]([O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:33])[CH3:31])=[O:28])[CH2:23][CH:24]([CH3:26])[CH3:25])=[O:20]>>[NH:1]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[C@H:2]([C:7]([NH:17][CH2:18][C:19]([NH:21][C@H:22]([C:27]([NH:29][C@H:30]([C:32]([O:34][CH2:35][C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)=[O:33])[CH3:31])=[O:28])[CH2:23][CH:24]([CH3:26])[CH3:25])=[O:20])=[O:9])[CH2:3][CH:4]([CH3:5])[CH3:6]