Trifluoroacetic acid → 8-(2-Fluoro-phenyl)-4-[3-(6-methyl-pyridazin-3-yl)-phenyl]-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 498517Notes

Reaction equation

HRID 498517 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2C=C[CH:17]=[CH:16][C:15]=2F)=[CH:10][C:9]=1[NH:21][C:22](=[O:39])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]2[N:33]=[N:34][C:35]([CH3:38])=[CH:36][CH:37]=2)[CH:27]=1)=O)(C)(C)C.[C:41](O)([C:43]([F:46])(F)F)=O>C(Cl)Cl>[F:46][C:43]1[CH:41]=[CH:17][CH:16]=[CH:15][C:14]=1[C:11]1[CH:12]=[CH:13][C:8]2[N:7]=[C:24]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]4[N:33]=[N:34][C:35]([CH3:38])=[CH:36][CH:37]=4)[CH:27]=3)[CH2:23][C:22](=[O:39])[NH:21][C:9]=2[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86589232(2'-Fluoro-3-{3-[3-(6-methyl-pyridazin-3-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert-butyl ester

Product 1

HCID 223179428-(2-Fluoro-phenyl)-4-[3-(6-methyl-pyridazin-3-yl)-phenyl]-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2′-fluoro-3-{3-[3-(6-methyl-pyridazin-3-yl)-phenyl]-3-oxo-propionylamino}-biphenyl-4-yl)-carbamic acid tert-butyl ester (Example M13) (292 mg, 0.541 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (181 mg).

Sources & evidence

ORD record
ord-f9be308d946c4c9e8deea6128733aad1
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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