HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 7-Dimethylamino-8-(2-fluoro-phenyl)-4-(3-pyridin-4-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | {2-Dimethylamino-2'-fluoro-5-(3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic acid tert-butyl ester | HCID 86589252 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-Dimethylamino-8-(2-fluoro-phenyl)-4-(3-pyridin-4-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 22317357 | — |
Reaction Steps
The title compound was prepared from {2-dimethylamino-2′-fluoro-5-(3-oxo-3-(3-pyridin-4-yl-phenyl)-propionylamino]-biphenyl-4-yl}-carbamic acid tert-butyl ester (Example M35) (302 mg, 0.531 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (208 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-9f376e41b2a14257bc27e1b850f4685e |
| Source note | uspto-grants-2005_09 |