HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 7-(Methyl-propyl-amino)-4-(3-pyrimidin-5-yl-phenyl)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | {5-(Methyl-propyl-amino)-2-[3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester | HCID 86589291 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-(Methyl-propyl-amino)-4-(3-pyrimidin-5-yl-phenyl)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 22317489 | — |
Reaction Steps
The title compound was prepared from {5-(methyl-propyl-amino)-2-[3-oxo-3-(3-pyrimidin-5-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (Example M90) (0.40 g, 0.70 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light orange solid (210 mg, 66%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-57eb6ccfe05b4bcea91fe54cb1054c15 |
| Source note | uspto-grants-2005_09 |