HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Diamino-4,5-difluorobenzene → HCID 22317904, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Diamino-4,5-difluorobenzene | HCID 2736755 | — |
| Reactant | 3-Oxo-3-(3-pyridin-3-yl-phenyl)-propionic acid tert-butyl ester | HCID 11266473 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 22317904 | HCID 22317904 | — |
Reaction Steps
The title compound was prepared from commercially available 4,5-difluoro-1,2-phenylendiamine (144 mg, 1.0 mmol) and 3-oxo-3-(3-pyridin-3-yl-phenyl)-propionic acid tert-butyl ester (Example K1) (297 mg, 1.0 mmol) in xylene (6 ml) under reflux conditions for 1.5 h according to the general procedure M. Obtained as an off-white solid (224 mg, 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-f1b2698498544723962efca050a4bbda |
| Source note | uspto-grants-2005_09 |