HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 8-Methyl-4-[3-(6-methyl-pyrazin-2-yl)-phenyl]-7-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (4-Methyl-2-{3-[3-(6-methyl-pyrazin-2-yl)-phenyl]-3-oxo-propionylamino}-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester | HCID 86589311 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Methyl-4-[3-(6-methyl-pyrazin-2-yl)-phenyl]-7-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 22317819 | — |
Reaction Steps
The title compound was prepared from (4-methyl-2-{3-[3-(6-methyl-pyrazin-2-yl)-phenyl]-3-oxo-propionylamino}-5-trifluoromethyl-phenyl)-carbamic acid tert-butyl ester (Example M118) (0.39 g, 0.74 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (237 mg, 78%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-e60d788b9b1249388a30d8e541822203 |
| Source note | uspto-grants-2005_09 |