反应详情

温度

110 °C

A mixture of 0.511 g (2 mmol) 1-chloro-4-(4-pyridylmethyl)phthalazine, 1.273 ml (10 mmol) (S)-1 phenylethylamine and 5 ml 1-butanol is stirred for 40 h at 110° C. After processing as described in Example 12 and equilibration for 65 hours at 20° C. and in room atmosphere, title compound is obtained with a water content of 10.53%; m.p. 190° C. (decomp.); ESI-MS: (M+H)+=341; [α]D20=+38.4±0.70 (c=1.507%, methanol).

1. waitas described in Example 12 and equilibration for 65 hours at 20° C. and in room atmosphere