HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(3-Pyridin-3-yl-phenyl)-7-pyrrolidin-1-yl-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | {2-[3-Oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-5-pyrrolidin-1-yl-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester | HCID 86589353 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(3-Pyridin-3-yl-phenyl)-7-pyrrolidin-1-yl-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 22317717 | — |
Reaction Steps
The title compound was prepared from {2-[3-oxo-3-(3-pyridin-3-yl-phenyl)-propionylamino]-5-pyrrolidin-1-yl-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (Example M169) (249 mg, 0.438 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a yellow solid (129 mg, 65%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-08539866204145829aa02541c0e48dfe |
| Source note | uspto-grants-2005_09 |