HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-Methyl-8-(trifluoromethoxy)-1,3-dihydro-1,5-benzodiazepin-2-one;2-phenylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | {2-[3-Oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-4-trifluoromethoxy-phenyl}-carbamic acid tert-butyl ester | HCID 86589370 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Methyl-8-(trifluoromethoxy)-1,3-dihydro-1,5-benzodiazepin-2-one;2-phenylpyridine | HCID 86589491 | — |
Reaction Steps
The title compound was prepared from {2-[3-oxo-3-(3-pyridin-2-yl-phenyl)-propionylamino]-4-trifluoromethoxy-phenyl}-carbamic acid tert-butyl ester (Example M186) (255 mg, 0.495 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (137 mg, 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-024a684e4d5a48969a9601240a6c0ff4 |
| Source note | uspto-grants-2005_09 |