反应详情

Under exclusion of air, 207 mg (0.66 mmol) 7-acetamino-1-chloro-4-(4-pyridylmethyl)-phthalazine is heated to boiling for 4 h in 2.7 ml 1-butanol with 253 mg (1.98 mmol) 4-chloroaniline. After cooling, the dark suspension is filtered off, washed with 1-butanol and ethanol, and dried to obtain title compound: m.p.: 260-265° C.; HPLC: tRet(Grad5-40)=10.9; FAB MS (M+H)+=404.

1. temperatureAfter cooling
2. filtrationthe dark suspension is filtered off
3. washwashed with 1-butanol and ethanol
4. customdried