Aniline → 7-Acetamino-1-anilino-4-(4-pyridylmethyl)phthalazine hydrochloride

HRID 49877Notes

Reaction equation

HRID 49877 reaction equation
[NH:1]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([CH2:16][C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)=[N:10][N:11]=[C:12]2[Cl:15])=[CH:7][CH:6]=1)[C:2]([CH3:4])=[O:3].[NH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>C(O)CCC>[ClH:15].[NH:1]([C:5]1[CH:14]=[C:13]2[C:8]([C:9]([CH2:16][C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)=[N:10][N:11]=[C:12]2[NH:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:7][CH:6]=1)[C:2]([CH3:4])=[O:3]

Participants

4

Reactant 2

HCID 6115AnilineHCID 227419517-Acetamino-1-chloro-4-(4-pyridylmethyl)phthalazine

Product 1

HCID 227419947-Acetamino-1-anilino-4-(4-pyridylmethyl)phthalazine hydrochloride

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

By analogy with Example 25, 250 mg (0.80 mmol) 7-acetamino-1-chloro-4-(4-pyridylmethyl)-phthalazine is reacted in 3.2 ml 1-butanol with 0.22 ml (2.4 mmol) aniline to obtain title compound: m.p.: 162-166° C.; HPLC: tRet(Grad5-40)=9.75; FAB MS (M+H)+=370.

Sources & evidence

ORD record
ord-1b7048452d3341d59641a81d163cc211
Source dataset
uspto-grants-2004_03
Patent number
US06710047B2

Reaction notes

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