HCID 69486428, compound → HCID 22317868, compound

HRID 498791Notes

Reaction equation

HRID 498791 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH3:14])[C:11]([Cl:15])=[CH:10][C:9]=1[NH2:16])(C)(C)C.C(O[C:23](=[O:42])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]2[CH:38]=[C:37]([CH3:39])[N:36]=[C:35]([NH:40][CH3:41])[N:34]=2)[CH:28]=1)=O)(C)(C)C>>[Cl:15][C:11]1[C:12]([CH3:14])=[CH:13][C:8]2[N:7]=[C:25]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([C:33]4[CH:38]=[C:37]([CH3:39])[N:36]=[C:35]([NH:40][CH3:41])[N:34]=4)[CH:28]=3)[CH2:24][C:23](=[O:42])[NH:16][C:9]=2[CH:10]=1

Participants

3

Reactant 2

HCID 69486428HCID 69486428, compoundHCID 69486983tert-Butyl (2-amino-4-chloro-5-methylphenyl)carbamate

Product 1

HCID 22317868HCID 22317868, compound

Procedure

The title compound was prepared from (2-amino-4-chloro-5-methyl-phenyl)-carbamic acid tert-butyl ester (Example J22) (128 mg, 0.5 mmol) and 3-[3-(6-methyl-2-methylamino-pyrimidin-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (Example K48) (188 mg, 0.55 mmol) according to the general procedure M and subsequent treatment of the crude product according to the general procedure N. Obtained as a light yellow solid (88 mg).

Sources & evidence

ORD record
ord-7d510129d9034e34bbbdf46338210435
Source dataset
uspto-grants-2005_09
Patent number
US06949542B2

Reaction notes

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