HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,5-Dichloro-1,2-phenylenediamine → 7,8-Dichloro-4-(3-pyrimidin-2-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,5-Dichloro-1,2-phenylenediamine | HCID 79297 | — |
| Reactant | 3-Oxo-3-(3-pyrimidin-2-yl-phenyl)-propionic acid tert-butyl ester | HCID 69487357 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 7,8-Dichloro-4-(3-pyrimidin-2-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 22317468 | — |
Reaction Steps
The title compound was prepared from 4,5-dichlorophenylenediamine (89 mg 0.5 mmol) and 3-oxo-3-(3-pyrimidin-2-yl-phenyl)-propionic acid tert-butyl ester (Example K44) (164 mg, 0.55 mmol) by refluxing in xylene according to the general procedure M. Obtained as a light yellow solid (127 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-e47b0addd3b640f5a5a5e0f6c390e9dd |
| Source note | uspto-grants-2005_09 |