HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 7-(Isopropyl-methyl-amino)-4-[3-(2-methyl-pyridin-4-yl)-phenyl]-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 86589495 | HCID 86589495 | — |
| Product | 7-(Isopropyl-methyl-amino)-4-[3-(2-methyl-pyridin-4-yl)-phenyl]-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one | HCID 22318021 | — |
Reaction Steps
The title compound was prepared from (4-chloro-5-(isobutyl-methyl-amino)-2-{3-[3-(2-methyl-pyridin-4-yl)-phenyl]-3-oxo-propionylamino}-phenyl)-carbamic acid tert-butyl ester (Example M277) (0.40 g, 0.71 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as an off-white solid (269 mg, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-7f22e4043a264198ba6ae0ab3867c6d6 |
| Source note | uspto-grants-2005_09 |