HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 22317902, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 86589497 | HCID 86589497 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22317902 | HCID 22317902 | — |
Reaction Steps
The title compound was prepared from (RS)-[5-(isobutyl-methyl-amino)-2-(3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionylamino)-4-trifluoromethyl-phenyl]-carbamic acid tert-butyl ester (Example M279) (5.82 g, 8.34 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light yellow solid (2.84 g, 69%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-0ba170372d4a42be8e624ec7553459c4 |
| Source note | uspto-grants-2005_09 |