HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 22318026, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 86589499 | HCID 86589499 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22318026 | HCID 22318026 | — |
Reaction Steps
The title compound was prepared from (RS)-[4-chloro-5-(isobutyl-methyl-amino)-2-(3-oxo-3-{3-[2-(tetrahydro-pyran-2-yloxymethyl)-pyridin-4-yl]-phenyl}-propionylamino)-phenyl]-carbamic acid tert-butyl ester (Example M281) (0.34 g, 0.51 mmol) by treatment with TFA in CH2Cl2 according to the general procedure N. Obtained as a light brown solid (152 mg, 64%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06949542B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-269b99e192744275b566a9a8c1294ab3 |
| Source note | uspto-grants-2005_09 |