Hydrazine hydrate (1:1) → 4-(4-Pyridylmethyl)-5,6,7,8-tetrahydro-1(2H)-phthalazinone

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Reaction Steps

A mixture of 0.773 g (3.4 mmol) 2-[4(1H)-pyridinylidene]-4,5,6,7-tetrahydro-inden-1,3-dione and 5 ml hydrazine hydrate is heated for 4 h under reflux. The title compound is obtained after cooling to 0° C., filtration, washing of the filter residue with water, then ether, and drying under HV (8 h, 100° C.); m.p. 193-194° C.; ESI-MS: (M+H)+=242.

Provenance & Evidence