反应详情

Geldanamycin (1.12 g, 2 mmol, 1 equiv) was added to anhydrous DCM (5 mL). NH3 in MeOH was added to this solution (9 mL, 100 mmol, 50 equiv) and was allowed to stir for 24 hours. At which point the reaction solution was diluted with DCM and extracted with water, followed by dilute HCl. The organic layer was collected washed with brine, dried over Na2SO4 and concentrated to yield a purple solid. This solid was recrystallized twice from acetone/heptanes to yield 0.239 of 17-amino-17-demethoxygeldanamycin.

1. extractionextracted with water
2. customThe organic layer was collected
3. washwashed with brine
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. customto yield a purple solid
7. customThis solid was recrystallized twice from acetone/heptanes