HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 49903Generated: October 27, 2026
Hydrochloric Acid → 1-Chloro-4-(4-pyrimidinylmethyl)phthalazine hydrochloride
https://huagongshe.com/reaction/49903
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-(4-pyrimidinylmethyl)-1(2H)-phthalazinone | HCID 10681389 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-Chloro-4-(4-pyrimidinylmethyl)phthalazine hydrochloride | HCID 22741971 | — |
Reaction Steps
850 mg (3.57 mmol) 4-(4-pyrimidinylmethyl)-1(2H)-phthalazinone in 15 ml acetonitrile is mixed with 1.78 ml (7.14 mmol) 4N HCl solution in dioxane and finally with 1.14 ml (12.5 mmol) phosphoryl chloride. After stirring for 36 h at 50° C., the red suspension is filtered and washed with acetonitrile: FAB MS (M−H)+=255. Further product is obtainable from the evaporated filtrate by distribution between dichloromethane and sat. NaHCO3 solution.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06710047B2 |
|---|
| Source dataset | uspto-grants-2004_03 |
|---|
| ORD ID | ord-f229d083509946d29a3f7ed6dda7eaaa |
|---|
| Source note | uspto-grants-2004_03 |
|---|
