Bromine → [2-(Bromoethyl)-6-(3-methoxyphenyl)pyrimidin-4-yl]-3-pyridylamine

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Reaction Steps

[2-ethyl-6-(3-methoxyphenyl)pyrimidin-4-yl]-3-pyridylamine 14 (synthesized with a procedure similar to the one previously described) (1 eq) is dissolved in acetic acid, then sodium acetate (2 eq) is added. To this mixture, a solution of bromine (1 eq) in acetic acid is added dropwise. The reaction is stirred at room temperature for 3 h. The reaction mixture is concentrated under reduced pressure, water is added and the solution basified (pH ˜10-11) with sat. aq. Na2CO3 solution. The product 15 crashes out, is filtered off, dried, and used as is in the following step.

Provenance & Evidence