HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → HCID 59789669, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Diethyl 2-[(3-formylphenyl)methylene]propane-1,3-dioate | HCID 59789754 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 59789669 | HCID 59789669 | — |
Reaction Steps
The solution of product 32 in toluene, from the previous reaction, is filtered, transferred to a round bottom flask, and ethylene glycol (2.4 eq) is added, followed by p-toulenesulfonic acid (0.5 eq). The reaction mixture is refluxed overnight with a Dean-Stark trap, then cooled down to room temperature, washed with sat. aq NaHCO3, brine, and dried (Na2SO4). Product 33 is not purified further but used as is in the following step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07767669B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-8146d2aaed544a2681dedd2f4845ef91 |
| Source note | uspto-grants-2010_08 |