Sodium Iodide → HCID 59420810, compound

Participants

Reaction Conditions

Reaction Steps

Sodium iodide (13.5 g, 90 mmol) was added to a solution of N-(4-(4,6-dichloropyrimidin-2-ylthio)phenyl)propionamide (5 g, 15 mmol) in 60% HI (50 ml). The reaction mixture was stirred at 70° C. for 10 h. The suspension was filtered. The recovered solid was taken up in saturated sodium bicarbonate aqueous solution (˜200 ml). Extractions were carried out with ethyl acetate (3×100 ml). The organic was washed with saturated sodium bicarbonate solution and brine. The solid was triturated in a minimum of dichloromethane to afford the title compound as a white solid (6 g, 78%). ES+ 512.

Provenance & Evidence