HuagongsheHuagongshe Chemistry Print Report · For research reference only
P-Anisidine → 3-(4-Methoxyanilino)-4,5-dimethyl-6-(pyridin-4-yl)methylpyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | 3-Chloro-4,5-dimethyl-6-(pyridin-4-yl)methylpyridazine | HCID 10776025 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-(4-Methoxyanilino)-4,5-dimethyl-6-(pyridin-4-yl)methylpyridazine | HCID 22742018 | — |
Reaction Steps
The compound is prepared from 0.070 g 3-chloro-4,5-dimethyl-6-(pyridin-4-yl)methylpyridazine and 0.129 g para-methoxyaniline in the manner described in Example 82A. Title compound is obtained after FC in CH2Cl2/Methanol 19/1. 1H-NMR (250 MHz, CDCl3): δ=8.45 (d, 2H); 7.45 (d, 2H); 7.10 (d, 2H); 6.85 (d, 2H); 6.05 (s, wide, 1H); 4.25 (s, 2H); 3.80 (s, 3H); 2.30 (s, 3H); 2.15 (s, 3H); 2.10 (s, 3H). ES-MS 321 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710047B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-36d559b8627241f7a2a08c2160e1ef03 |
| Source note | uspto-grants-2004_03 |