4-Chloro-1,2-diaminobenzene → HCID 136059437, Verbindung

Beteiligte Stoffe

Reaktionsschritte

A mixture of 6-oxo-1,6-dihydropyridazine-3-carboxylic acid (0.790 g, 5.000 mmol) and 4-chlorobenzene-1,2-diamine (0.720 g, 5.000 mmol) was added to pre-heated (150° C.) polyphosphoric acid (5 g) with stirring, and the reaction was stirred at 150 C for 2 hours. Water was added to the reaction mixture, and the resulting solution was neutralized with NaHCO3, and extracted with ethyl acetate. The organic phase was dried and evaporated to afford 6-(6-chloro-1H-benzoimidazol-2-yl)-2H-pyridazin-3-one as a dark solid (0.210 g, 0.85 mmol, 17% yield).

Herkunft & Nachweise