Formaldehyde → HCID 15261642, compound

Participants

Reaction Steps

A mixture of 2-amino-1-phenylethanol (1.000 g, 0.007 mmol) and formaldehyde (37%, 0.92 mL, 0.012 mmol) in THF (10 mL) was heated to reflux for 3 h and allowed to cool to ambient temperature with stirring over night. The mixture was concentrated and the residue was dissolved in dichloromethane. The resulting solution was washed with water. The organic phase was dried over anhydrous sodium sulphate, concentrated in vacuo. The yellowish residue was purified by column chromatography to obtain the title compound in 91% yield (0.990 g). MS (ES+) m/z 419.2 (M+1).

Provenance & Evidence