Methyl iodide → 1-Methyl-3-{6-[4-(2-trifluoromethylbenzoyl)piperazin-1-YL]pyridazin-3-YL}imidazolidin-2-one

Participants

Reaction Steps

Following the procedure as described in Example 2, making variations only as required to use 1-iodomethane in place of 1-iodo-3-methylbutane to react with 1-{6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazin-3-yl}imidazolidin-2-one, the title compound was obtained as a white solid in 39% yield (0.020 g). 1H NMR (300 MHz, CDCl3) δ 8.47-8.44 (m, 1H), 7.71 (d, J=7.8 Hz, 1H), 7.62-7.49 (m, 2H), 7.33 (d, J=7.8 Hz, 1H), 7.03-6.99 (m, 1H), 4.08 (t, J=7.8 Hz, 2H), 4.02-3.82 (m, 2H), 3.65-3.42 (m, 6H), 3.31-3.28 (m, 2H), 2.89 (m, 3H). 13C NMR (75 MHz, CD3OD) δ 170.4, 135.4, 133.9, 131.0, 128.8, 127.99, 127.91, 127.85, 47.8, 46.7, 46.6, 45.1, 42.5, 42.4, 31.01, 30.8. MS (ES+) m/z 435 (M+1).

Provenance & Evidence