2-(Trifluoromethyl)benzoyl chloride → HCID 11576726, compound

Participants

Reaction Steps

Following the procedure as described in Example 6, making variations only as required to use 6-chloro-2-(6-piperazin-1-yl-pyridazin-3-yl)-1H-benzoimidazole in place of 2-(6-piperazin-1-ylpyridin-3-yl)-1H-benzoimidazole to react with 2-trifluoromethyl-benzoyl chloride, the title compound was obtained as a white powder in 24% yield (0.118 g). 1H NMR (300 MHz, CDCl3) δ 13.4 (m, 1H), 8.15 (d, J=9.5 Hz, 1H), 7.82 (d, J=7.8 Hz, 1H), 7.76 (t, J=7.5 Hz, 1H), 7.70-7.63 (m, 2H), 7.54 (d, J=7.5 Hz, 1H), 7.48-7.45 (m, 1H), 7.42 (d, J=9.6 Hz, 1H), 7.24-7.16 (m, 1H), 3.83-3.59 (m, 6H), 3.30-3.20 (m, 2H). MS (ES+) m/z 487.4 (M+1).

Provenance & Evidence