Propylenediamine → (5-Fluoro-2-trifluoromethylphenyl)-{4-[5-(5-methyl-4,5-dihydro-1H-imidazol-2-YL)pyridin-2-YL]piperazin-1-YL}methanone

Participants

Reaction Steps

Following the procedure as described in Example 10, making variations only as required to use 1,2-diaminopropane in place of 1,2-diaminopentane to react with 6-[4-(5-fluoro-2-trifluoromethylbenzoyl)piperazin-1-yl]nicotinic acid, the title compound was obtained as a pale yellow solid in 46% yield (0.260 g). 1H NMR (300 MHz, CD3OD) δ 8.63 (d, J=2.3 Hz, 1H), 7.98-7.86 (m, 2H), 7.48-7.35 (m, 2H), 6.99 (d, J=9.2 Hz, 1H), 4.55-4.41 (m, 1H), 3.98-3.33 (m, 10H), 1.44 (d, J=6.3 Hz, 3H). MS (ES+) m/z 436 (M+1).

Provenance & Evidence