反应详情

温度

22 °C

1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-3-{4-[1-(tert-butoxy)carbonyl-piperidin-4-yloxy]phenyl}urea (Example 1. below, 2.25 g, 4.77 mmol) is suspended in a solution of trifluoroacetic acid in dichloromethane (25% v/v, 100 mL). The reaction mixture is stirred at 22° C. for 15 min. After removal of the solvent, the oily residue is neutralized with sodium hydroxide solution to pH 12 and extracted with dichloromethane (6×50 mL). The combined-organic phases are dried over anhydrous sodium sulfate and concentrated to yield a yellow solid (2.28 g, ES+(m/z) 372.1 [M+H]).

1. customAfter removal of the solvent
2. extractionextracted with dichloromethane (6×50 mL)
3. dry with materialThe combined-organic phases are dried over anhydrous sodium sulfate
4. concentrationconcentrated
5. customto yield a yellow solid (2.28 g, ES+(m/z) 372.1 [M+H])