HCID 86625257, compound → HCID 59420876, compound

Participants

Reaction Steps

A mixture of 1-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-3-{3-[1-(benzyloxy)-carbonyl-piperidin-4-yloxy]phenyl}urea. (Example 54. below, 6.62 g, 13.1 mmol) and 10% palladium on carbon (1 g) in ethanol (200 mL) is stirred at 22° C. under hydrogen gas for 2.5 hours. The catalyst is removed by filtration. The filtrate is concentrated to give brown oil, which solidifies upon standing at 22° C. over weekend. The residue is purified on a silica gel chromatography by eluting with methanol and dichloromethane. A peach color solid is obtained (3.51 g, 72% yield, ES+(m/z) 372.3 [M+H]).

Provenance & Evidence