Dicyclohexylcarbodiimide → HCID 52264683, compound

Participants

Reaction Conditions

Reaction Steps

To an ice-cooled slurry of 4-N-BOC-amino-piperidine (400.8 mg, 2.0 mmol), 1-hydroxybenzotriazole (HOBt, 342.3 mg, 2.53 mmol), and p-(methylsulfonyl)-benzoic acid (445.9 mg, 2.23 mmol) in dichloromethane (6 mL) is added 1,3-dicyclohexylcarbodiimide (DCC, 496.7 mg, 2.40 mmol). The reaction mixture is stirred at 22° C. for 23 hours. The crude product is purified on a silica gel chromatography with ethyl acetate-hexanes to provide a white solid (692.9 mg, 90.6% yield, ES+(m/z) 383.1 [M+H]).

Provenance & Evidence