Hydrochloric Acid → HCID 68457685, compound

Participants

Reaction Steps

4-{4-[3-(5-tert-Butyl 2-ethyl-2H-pyrazol-3-yl)-ureido]-benzyl}-piperazine-1-carboxylic acid tert-butyl ester (105 mg, 0.216 mmol) is dissolved in dichloromethane (3 mL) and a 4M solution of HCl in 1,4-dioxane (0.86 mL, 3.5 mmol) is added and the mixture stirred at room temperature for 2 hours. After removal of solvent, the residue is triturated with diethyl ether and air-dried to obtain the title compound (99 mg, 99% yield, ES+(m/z) 385 [M+H]).

Provenance & Evidence