HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Nitrophenyl)piperazine → 1-Boc-4-(4-Nitrophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Nitrophenyl)piperazine | HCID 80447 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Boc-4-(4-Nitrophenyl)piperazine | HCID 3380696 | 100% |
Reaction Steps
1-(4-Nitro-phenyl)-piperazine (2 g, 9.65 mmol) is dissolved in dichloromethane (50 mL) and (BOC)2O is added (2.10 g, 9.65 mmol). The mixture is stirred at room temperature overnight. Solvent removal affords a yellow solid (2.96 g, 100% yield, ES+(m/z) 308 [M+H]).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07767674B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-5e0036a30e5c4b82945ae2d9c248653f |
| Source note | uspto-grants-2010_08 |