Diisopropylethylamine → HCID 59420874, compound

Participants

Reaction Conditions

Reaction Steps

Nitrogen gas is bubbled through a solution of [4-(4-amino-phenoxy)-piperidin-1-yl]-(2,6-dichlorophenyl)-methanone (47 mg, 0.12 mmol) and (5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-carbamic acid 2,2,2-trichloro-ethyl ester (42 mg, 0.12 mmol) in DMSO (1.5 mL) for 5 min. Next, N,N-diisopropylethylamine (40 μL, 0.24 mmol) is added. The reaction mixture is stirred at 60° C. for 6 hours. Then, DMSO is removed by passing the reaction mixture through an SCX column. The crude product is obtained by eluting the SCX column with 2M ammonia in methanol and purifying the residue on silica gel with ethyl acetate-hexanes (25%) to give a white solid (ES+(m/z) 544.2 [M+H]).

Provenance & Evidence