Dimethyl Sulfoxide → HCID 59420881, compound

Participants

Reaction Conditions

Reaction Steps

Nitrogen gas is bubbled through a solution of (4-amino-piperidin-1-yl)-(4-methylsulfonyl-phenyl)-methanone (141.6 mg, 0.50 mmol) and (5-tert-butyl-2-tolyl-2H-pyrazol-3-yl)-carbamic acid 2,2,2-trichloro-ethyl ester (204.8 mg, 0.51 mmol) in DMSO (2 mL) for 2 minutes. Next, N,N-diisopropylethylamine (0.20 mL) is added. The reaction mixture is stirred at 60° C. for 6 hours. The crude product is purified on a silica gel chromatography with ethyl acetate to give a white solid (261.2 mg, 97.2%, ES+(m/z) 538.3 [M+H]).

Provenance & Evidence