tert-Butylacetic acid → HCID 59420859, compound

Participants

Reaction Steps

The title compound is prepared by reaction of 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-(4-piperazin-1-yl-phenyl)-urea (0.20 g, 0.46 mmol) with 0.51 mmol of 3,3-Dimethyl-butyric acid, (0.06 g, 0.46 mmol) of 1-Hydroxybenzotriazole hydrate and (0.8 g, 0.46 mmol) of polymer supported carbodiimide, dissolved in 16 mL of CH2Cl2. Mixture is stirred at r.t.o.n. It is filtered and the resin is washed with CH2Cl2 Solvent is evaporated and the residue is purified with an SCX cartridge eluting with NH4OH/CH3OH 2 N. ES+(m/z) 531 [M+H].

Provenance & Evidence