Pyridine → 4-Butylphenyl acetate

HRID 499217Notes

Reaction equation

HRID 499217 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1.[CH3:12][C:13](OC(C)=O)=[O:14].N1C=CC=CC=1>ClCCl>[C:13]([O:11][C:8]1[CH:7]=[CH:6][C:5]([CH2:4][CH2:3][CH2:2][CH3:1])=[CH:10][CH:9]=1)(=[O:14])[CH3:12]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 154204-Butylphenol

Product 1

HCID 127612574-Butylphenyl acetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 10 g of 4-n-butylphenol, 10 ml of Ac2O and 8 ml of pyridine is stirred at reflux in 10 ml of dichloromethane. After 2 hours, the medium is cooled to ambient temperature, diluted in dichloromethane, washed with water, washed with a 1M HCl solution, washed in a saturated CuSO4 solution, washed with water, and dried over MgSO4. After evaporation, 10.8 g of the expected compound are recovered in the form of an oil.

Workup

  1. washwashed with water
  2. washwashed with a 1M HCl solution
  3. washwashed in a saturated CuSO4 solution
  4. washwashed with water
  5. dry with materialdried over MgSO4
  6. customAfter evaporation, 10.8 g of the expected compound
  7. customare recovered in the form of an oil

Sources & evidence

ORD record
ord-453c636a0f814fe68fa85c5caef00da8
Source dataset
uspto-grants-2010_08
Patent number
US07767681B2

Reaction notes

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