HCID 68453456, compound → HCID 7160762, compound

HRID 499223Notes

Reaction equation

HRID 499223 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C@@H:15]2[CH2:20][CH2:19][CH2:18][N:17]([CH3:21])[CH2:16]2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>CO.[Pd]>[CH3:21][N:17]1[CH2:18][CH2:19][CH2:20][C@@H:15]([CH2:14][N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH2:16]1

Participants

5

Reactant 2

HCID 68453456HCID 68453456, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 7160762HCID 7160762, compoundYield 95.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 3.46 g of the compound obtained in step 3.3, in 100 ml of methanol, is hydrogenated in the presence of 1.9 g of wet 10% Pd/C under 800 kPa of hydrogen pressure at 40° C. for 3 hours. The medium is filtered and then evaporated, to give 2.26 g of a colourless oil.

Workup

  1. filtrationThe medium is filtered
  2. customevaporated

Sources & evidence

ORD record
ord-455ef249485e441285ca80322289dc5b
Source dataset
uspto-grants-2010_08
Patent number
US07767681B2

Reaction notes

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