HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Tert-butyl 4-(piperidine-2-carbonyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1,3-Cyclohexadiene | HCID 11605 | — |
| Reactant | 4-(1-Benzyloxycarbonylpiperidine-2-carbonyl)piperazine-1-carboxylic acid tert-butyl ester | HCID 68457842 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Tert-butyl 4-(piperidine-2-carbonyl)piperazine-1-carboxylate | HCID 50986447 | 82.7% |
Reaction Steps
3.9 ml of cyclohexadiene and then 1.3 g of 10% Pd/C with a 50% water content are added, under an inert atmosphere, to a solution of 1.79 g of the compound obtained in step 5.1, in 14 ml of EtOH. The medium is stirred at AT for 24 hours and then filtered. The filtrate is evaporated, to give 1.02 g of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07767681B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-30f8888ab79e487b94709f7e7ed92e07 |
| Source note | uspto-grants-2010_08 |