HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 499250Generated: October 31, 2026
Triethylamine → N-Benzyl4-(2-chlorophenyl)-N-isopropyl-2-morpholinopyrimidine-5-carboxamide
https://huagongshe.com/reaction/499250
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Isopropylbenzylamine | HCID 66024 | — |
| Reactant | 4-(2-Chlorophenyl)-2-morpholino pyrimidine-5-carboxylic acid | HCID 21712446 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-Benzyl4-(2-chlorophenyl)-N-isopropyl-2-morpholinopyrimidine-5-carboxamide | HCID 11690962 | — |
Reaction Steps
In a microwave tube was added 1 eq. of 4-(2-chlorophenyl)-2-morpholino pyrimidine-5-carboxylic acid (80 mg), 1.1 eq. of isopropyl benzylamine (43 mL), 2.5 eq. of triethylamine (80 mL) and 1.2 eq. of BtSO2Me in 4 mL of dioxane. The reaction mixture was heated to 160° C./300 W for 1200 sec. The crude product was purified by prep HPLC. ES+=451.0. NMR confirmed the structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07767680B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-c152799f4c644bffb81d245a3456f2a1 |
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| Source note | uspto-grants-2010_08 |
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