Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzoic acid, 2-mercapto-, methyl ester | HCID 21009 | — |
| Reactant | Pyrazinecarbonitrile | HCID 73172 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 22939573 | HCID 22939573 | 22.4% |
Reaction Steps
A mixture of methyl thiosalicylate (1.68 g, 10.0 mmol), cyanopyrazine (1.06 g, 10.1 mmol), triethylamine (2.10 ml, 15.1 mmol) and toluene (10.0 ml) was refluxed at 120° C. for 8 hrs. The solvent was evaporated and the residue was recrystallized from dioxane-hexane to give the titled compound (0.54 g, 22%) as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07767665B2 |
|---|
| Source dataset | uspto-grants-2010_08 |
|---|
| ORD ID | ord-bb36c423653c4fc8b7ff6d78b228beb8 |
|---|
| Source note | uspto-grants-2010_08 |
|---|
